Reproduction Abstracts

Introduction: This work adapts a novel ovary culture technique, devised by De Felici’s group, for assessing the ovotoxicity of two chemotherapeutic drugs, cisplatin and doxorubicin. Previous work from our laboratory used cultures of intact neonatal ovaries to determine the effects of the two drugs, showing that both cisplatin and doxorubicin are moderately ovotoxic.Methods: Here, ovaries collected from newborn WT mice were cultured as by De Felici. ...